5-Amino-1MQ — Selective NNMT Inhibitor

5-Amino-1MQ (50mg) is supplied in Australia by Daza Enhanced with fast domestic shipping to all states and territories.

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that consumes nicotinamide (the precursor to NAD+) and S-adenosylmethionine (SAM). NNMT activity is elevated in white adipose tissue in obese subjects across published preclinical work, and is studied as a regulator of adipocyte energy metabolism, methylation pool homeostasis, and the NAD+ salvage pathway.

By inhibiting NNMT, 5-Amino-1MQ has been investigated in preclinical models for effects on adipocyte size, fat mass, methylation balance, and metabolic flexibility. Published rodent studies have reported reductions in white-adipose-tissue mass and improvements in metabolic markers in diet-induced obese models, without effect on food intake. Though a small molecule rather than a peptide, it is supplied as a powder for reconstitution with bacteriostatic water and subcutaneous injection — the same handling as the peptide compounds it is often discussed alongside.

Key Research Areas for 5-Amino-1MQ

• NNMT Enzyme Research — Studied as a selective small-molecule probe of NNMT activity in adipose and other tissues
• Adipose Biology — Investigated in preclinical models for effects on adipocyte size and white-adipose-tissue mass
• NAD+ Salvage Pathway — Examined for indirect effects on NAD+ availability via reduced nicotinamide methylation
• Methylation Pool Research — Studied for impact on SAM consumption and downstream methylation balance
• Metabolic Flexibility Research — Investigated in diet-induced obese rodent models for energy-expenditure and substrate-use endpoints

Supplied as high-purity powder. 50mg per vial. Fast domestic shipping across Australia, with batch-specific CoA information available in our CoA Library.

⚠ For in-vitro research and laboratory use only. Not for human consumption.